360° Chat-TMD
The 360° Collaborative Hub for AI in TMD Research (360° Chat-TMD) is a national, patient-centered initiative creating robust models to establish new clinical standards for TMD care based on risk, severity, and comorbid conditions.
Provides a complete end-to-end platform for synthetically generating comprehensive, multimodal, and realsitic TMD case-studies, instrumented participant cohorts, and simulated data. The TMD-Simulator supports exploratory, qualitative, and quantitative analytics of the TMD datasets and provides access to AI-enhanced clinical decision support.
Temporomandibular disorders (TMD) are a significant public health problem, affecting up to 10% of the population with pain and compromised joint function. As the second most prevalent musculoskeletal condition after chronic low back pain, TMD incurs an estimated annual societal cost of $4 billion.
The complexity of TMD, its often subjective symptoms, and its overlap with other chronic pain conditions call for an interdisciplinary, whole-person approach to improve diagnosis and develop effective, evidence-based therapies. Our center was established to bridge critical knowledge gaps and translate research discoveries into clinical practice.
Professor and 360 TMD Center PI.
Professor and 360 TMD Center co-PI.
Professor and 360 TMD Center co-PI.
Assistant Professor and 360 TMD Center co-PI.
Assistant Professor and 360 TMD Center co-PI.
Professor and SDM Dean.
Professor and BDSC co-Lead.
Harvard University Corresponding Member of the Facility and OTEC Project Lead.
Assistant Professor.
Clinical Faculty.
Henry P. Tappan Professor and BDSC Lead.
Drive discovery and innovation by integrating life sciences, engineering, AI, and health technologies to solve clinically-defined problems.
Conduct comprehensive research on the multifaceted biological, behavioral, and environmental determinants of TMD to foster a deeper understanding of effective treatments.
Pioneer new diagnostic tools and therapeutic interventions by leveraging cutting-edge technology, Gen AI modeling, and insights from our research.
Bolster the field of TMD research through rigorous training and workforce development, ensuring a robust pipeline of skilled professionals.
This project aims to understand the mechanisms of TMJ Osteoarthritis and associated pain using a multi-level approach in animal models. The goal is to develop more effective, evidence-based treatments that can promote tissue regeneration, reduce pain, and restore function.
This project develops and validates robust mechanistic and clinical models for classifying and predicting TMD. It uses advanced AI/ML, deep-phenotyping, and patient data to enable precision medicine and create clinically actionable tools for personalized TMD management.
The Bioinformatics and Data Science Core is the computational and analytical hub for the Temporomandibular Disorder (TMD) IMPACT Center. BDSC provides critical infrastructure and expertise for data management, integration, analysis, and sharing across all Center components. The Core leverages state-ofthe-art technologies, including artificial intelligence (AI), such as machine learning (ML), deep learning, natural language processing (NLP), generative AI modeling (GAIM), and federated learning, to maximize the scientific value of both existing institutional and population health datasets and newly generated Center research data. To advance patient-centered translational research through innovative computational methods, data integration, and analytics, BDSC will utilize Findable, Accessible, Interoperable, and Reusable (FAIR) data practices1 across all TMD Center's activities. BDSC develops and supports the TMD-Simulator.
OTEC validates evidence-based curricula developed at the TMD Center to train the future Temporomandibular Disorder (TMD) biomedical workforce. By integrating AI-powered searchable content and interactive modules that emphasize inclusivity and patientcentered insights, OTEC aim to ensure equitable knowledge dissemination across various stakeholders, including board-certified specialists, early learners, clinicians, investigators, and patients by developing tailored curricula, structured mentorship, and individualized learning plans for early-career researchers. OTEC engages Patient Advocacy Groups (PAGs) in the development and evaluation processes to ensure that the educational resources are relevant and effective.
The 360 TMD Center will present at the Harvard School of Dental medicine (HSDM) AI Global Summit, November 14-15, 2025.
The Pain and Headache Rounds disseminates TMD knowledge through interactive seminars and forums that inspire collaboration, reflection, and discourse. The rounds series focuses on providing evidence-based content, while exploring empirical support for novel avenues of patient care.
Our center is a proud partnership between leading institutions including the University of Michigan, Harvard University, and Mass General Brigham, alongside dedicated patient communities. We are leveraging our collective expertise to address the challenges of TMD head-on.
For detailed information about our specific research, publications, team, and ongoing initiatives, please visit the 360 TMD Websites.